Professor Jacqui Matthews

Research interests

The 30,000 or so genes in your genome encode proteins that work together in a coordinated fashion to regulate every biological process in the body.

Jacqui Matthews' team is interested in finding out not just how proteins achieve these important biological processes, but also whether artificial regulation of these activities through the design of specific protein inhibitors is possible.

In particular, they are investigating the protein-protein and protein-DNA interactions that occur during normal cellular development and comparing them with interactions that cause diseases states such as T-cell leukemia, beta-thalassaemia and breast cancer. To do this, they are using a range of techniques including: molecular biology, biophysical methods and structural methods.

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